SCOPe 2.08: Domain d6pp9b_: 6pp9 B:

Lineage for d6pp9b_ (6pp9 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (36 PDB entries)
   Uniprot Q02750 61-381

8. Domain d6pp9b_: 6pp9 B: [375831]
   Other proteins in same PDB: d6pp9a_
   automated match to d5hzea_
   complexed with anp, cl, gol, lcj, mg, so4

Details for d6pp9b_

PDB Entry: 6pp9, 2.59 Å

PDB Description: crystal structure of braf:mek1 complex

PDB Compounds: (B:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d6pp9b_:

Sequence, based on SEQRES records:

>d6pp9b_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eeleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmark
lihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkk
agripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlid
amanafvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgc
qvegdaaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsgvfslefqdf
vnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq

Sequence, based on observed residues (ATOM records):

>d6pp9b_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eeleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmark
lihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkk
agripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlid
amanafvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmpma
ifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeev
dfagwlcstiglnq

Timeline for d6pp9b_:

• d6pp9b_ first appeared in SCOPe 2.07