SCOPe 2.08: Domain d6kdfp1: 6kdf P:14-340

Lineage for d6kdfp1 (6kdf P:14-340)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.0: automated matches [191423] (1 protein)
   not a true family

6. Protein automated matches [190603] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [329721] (12 PDB entries)

8. Domain d6kdfp1: 6kdf P:14-340 [374775]
   Other proteins in same PDB: d6kdfc2, d6kdfd2, d6kdfe2, d6kdff2, d6kdfh2, d6kdfj2, d6kdfl2, d6kdfn2, d6kdfp2
   automated match to d5grhb_

Details for d6kdfp1

PDB Entry: 6kdf, 3.05 Å

PDB Description: crystal structure of the alpha beta heterodimer of human idh3 in apo form.

PDB Compounds: (P:) Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

SCOPe Domain Sequences for d6kdfp1:

Sequence, based on SEQRES records:

>d6kdfp1 c.77.1.0 (P:14-340) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sfpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlsevqnmaseekleqvlssmken
kvaiigkihtpmeykgelasydmrlrrkldlfanvvhvkslpgymtrhnnldlviireqt
egeysslehesargvieclkivtraksqriakfafdyatkkgrgkvtavhkanimklgdg
lflqcceevaelypkikfetmiidnccmqlvqnpyqfdvlvmpnlygniidnlaaglvgg
agvvpgesysaeyavfetgarhpfaqavgrnianptamllsasnmlrhlnleyhssmiad
avkkvikvgkvrtsdmggyatchdfte

Sequence, based on observed residues (ATOM records):

>d6kdfp1 c.77.1.0 (P:14-340) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sfpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlsekleqvlssmkenkvaiigki
asydmrlrrkldlfanvvhvkslpgymtrhnnldlviireqtegeysslehesargviec
lkivtraksqriakfafdyatkkgrgkvtavhkanimklgdglflqcceevaelypkikf
etmiidnccmqlvqnpyqfdvlvmpnlygniidnlaaglvggagvvpgesysaeyavfet
garhpfaqavgrnianptamllsasnmlrhlnleyhssmiadavkkvikvgkvrtsdmgg
yatchdfte

Timeline for d6kdfp1:

• d6kdfp1 first appeared in SCOPe 2.07