SCOPe 2.08: Domain d6i1sa1: 6i1s A:172-499

Lineage for d6i1sa1 (6i1s A:172-499)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d6i1sa1: 6i1s A:172-499 [373951]
   Other proteins in same PDB: d6i1sa2, d6i1sb1, d6i1sb2
   automated match to d3h9ra_
   complexed with e26, edo, so4

Details for d6i1sa1

PDB Entry: 6i1s, 1.52 Å

PDB Description: crystal structure of the acvr1 (alk2) kinase in complex with fkbp12 and the inhibitor e6201

PDB Compounds: (A:) Activin receptor type-1

SCOPe Domain Sequences for d6i1sa1:

Sequence, based on SEQRES records:

>d6i1sa1 d.144.1.7 (A:172-499) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ttnvgdstladlldhsctsgsgsglpflvqrtvarqitllecvgkgrygevwrgswqgen
vavkifssrdekswfretelyntvmlrhenilgfiasdmtsrhsstqlwlithyhemgsl
ydylqlttldtvsclrivlsiasglahlhieifgtqgkpaiahrdlksknilvkkngqcc
iadlglavmhsqstnqldvgnnprvgtkrymapevldetiqvdcfdsykrvdiwafglvl
wevarrmvsngivedykppfydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptltsla
klmkecwyqnpsarltalrikktltkid

Sequence, based on observed residues (ATOM records):

>d6i1sa1 d.144.1.7 (A:172-499) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ttnvgdstladlldhsgsglpflvqrtvarqitllecvgkgrygevwrgswqgenvavki
fssrdekswfretelyntvmlrhenilgfiasdmtsstqlwlithyhemgslydylqltt
ldtvsclrivlsiasglahlhieifgtqgkpaiahrdlksknilvkkngqcciadlglav
mhsqstnqldvgnnprvgtkrymapevldetiqvdcfdsykrvdiwafglvlwevarrmv
sngivedykppfydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwy
qnpsarltalrikktltkid

Timeline for d6i1sa1:

• d6i1sa1 first appeared in SCOPe 2.07