SCOPe 2.08: Domain d6agxa_: 6agx A:

Lineage for d6agxa_ (6agx A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d6agxa_: 6agx A: [373146]
   automated match to d3b2ta_
   complexed with 9wx

Details for d6agxa_

PDB Entry: 6agx, 2.95 Å

PDB Description: the cocrystal structure of fgfr2 bound with compound 14 harboring 5h- pyrrolo[2,3-b]pyrazine scaffold

PDB Compounds: (A:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d6agxa_:

Sequence, based on SEQRES records:

>d6agxa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
elpedpkwefprdkltlgkplgegcfgqvvmaeavgidkdkpkeavtvavkmlkddatek
dlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmey
sydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdltarnvlvtennvmkiadfg
lardinnidyykkttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypg
ipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Sequence, based on observed residues (ATOM records):

>d6agxa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
elpedpkwefprdkltlgkplgegcfgqvvmaeavgidkdkpkeavtvavkmlkddatek
dlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrpinrvp
eeqmtfkdlvsctyqlargmeylasqkcihrdltarnvlvtennvmkiadfglardiykk
ttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeg
hrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Timeline for d6agxa_:

• d6agxa_ first appeared in SCOPe 2.07