SCOPe 2.08: Domain d6e6ef_: 6e6e F:

Lineage for d6e6ef_ (6e6e F:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-src tyrosine kinase [56155] (3 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56156] (14 PDB entries)

8. Domain d6e6ef_: 6e6e F: [372315]
   automated match to d4mxob_
   complexed with hvy

Details for d6e6ef_

PDB Entry: 6e6e, 2.15 Å

PDB Description: dgy-06-116, a novel and selective covalent inhibitor of src kinase

PDB Compounds: (F:) Proto-oncogene tyrosine-protein kinase Src

SCOPe Domain Sequences for d6e6ef_:

Sequence, based on SEQRES records:

>d6e6ef_ d.144.1.7 (F:) c-src tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkkl
rheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaalyg
rftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcq
cwrkepeerptfeylqafledyftstepqyqpgenl

Sequence, based on observed residues (ATOM records):

>d6e6ef_ d.144.1.7 (F:) c-src tyrosine kinase {Human (Homo sapiens) [TaxId: 9606]}
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkkl
rheklvqlyavvseepiyivteymskgslldflkgetgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfglarliakfpikwtapeaalygrftiksdvws
fgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerp
tfeylqafledyftstepqyqpgenl

Timeline for d6e6ef_:

• d6e6ef_ first appeared in SCOPe 2.07