SCOPe 2.07: Domain d6o2zb1: 6o2z B:3-414

Lineage for d6o2zb1 (6o2z B:3-414)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries)
   Uniprot O75874

8. Domain d6o2zb1: 6o2z B:3-414 [370999]
   Other proteins in same PDB: d6o2za2, d6o2zb2
   automated match to d1t0la_
   complexed with gol, ljv, nap; mutant

Details for d6o2zb1

PDB Entry: 6o2z, 2.5 Å

PDB Description: crystal structure of idh1 r132h mutant in complex with compound 32

PDB Compounds: (B:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d6o2zb1:

Sequence, based on SEQRES records:

>d6o2zb1 c.77.1.1 (B:3-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Sequence, based on observed residues (ATOM records):

>d6o2zb1 c.77.1.1 (B:3-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhadqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmyn
qdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqki
wyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktve
aeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsi
etieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Timeline for d6o2zb1:

• d6o2zb1 is new in SCOPe 2.07-stable
  
• d6o2zb1 appears in the current release, SCOPe 2.08