SCOPe 2.08: Domain d6nvlc_: 6nvl C:

Lineage for d6nvlc_ (6nvl C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (47 PDB entries)

8. Domain d6nvlc_: 6nvl C: [370960]
   automated match to d4v04b_
   complexed with so4, xl6

Details for d6nvlc_

PDB Entry: 6nvl, 2.7 Å

PDB Description: fgfr1 complex with n-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy) pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide

PDB Compounds: (C:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d6nvlc_:

Sequence, based on SEQRES records:

>d6nvlc_ d.144.1.7 (C:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
lpedprwelprdrlvlgkplgegcfgqvvlaeaigldkdkpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgleys
ynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgl
ardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgv
pveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalt

Sequence, based on observed residues (ATOM records):

>d6nvlc_ d.144.1.7 (C:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
lpedprwelprdrlvlgkplgqvvlaeaigldpnrvtkvavkmlkstekdlsdlisemem
mkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgqlsskdlvscayqv
argmeylaskkcihrdlaarnvlvtednvmkiadfglhhidyykktpvkwmapealfdri
ythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdc
whavpsqrptfkqlvedldrivalt

Timeline for d6nvlc_:

• d6nvlc_ first appeared in SCOPe 2.07