SCOPe 2.01: Domain d7pckd_: 7pck D:

Lineage for d7pckd_ (7pck D:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein (Pro)cathepsin K [54028] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [54029] (31 PDB entries)
   Uniprot P43235 116-329 ! Uniprot P43235 115-329

8. Domain d7pckd_: 7pck D: [37082]
   contains propeptide

Details for d7pckd_

PDB Entry: 7pck, 3.2 Å

PDB Description: crystal structure of wild type human procathepsin k

PDB Compounds: (D:) protein (procathepsin k)

SCOPe Domain Sequences for d7pckd_:

Sequence, based on SEQRES records:

>d7pckd_ d.3.1.1 (D:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
lypeeildthwelwkkthrkqynnkvdeisrrliweknlkyisihnleaslgvhtyelam
nhlgdmtseevvqkmtglkvplshsrsndtlyipewegrapdsvdyrkkgyvtpvknqgq
cgscwafssvgalegqlkkktgkllnlspqnlvdcvsendgcgggymtnafqyvqknrgi
dsedaypyvgqeescmynptgkaakcrgyreipegnekalkravarvgpvsvaidaslts
fqfyskgvyydescnsdnlnhavlavgygiqkgnkhwiiknswgenwgnkgyilmarnkn
nacgianlasfpkm

Sequence, based on observed residues (ATOM records):

>d7pckd_ d.3.1.1 (D:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
lypeeildthwelwkkthrkqynnkvdeisrrliweknlkyisihnleaslgvhtyelam
nhlgdmtseevvqkmtglkvlyiapdsvdyrkkgyvtpvknqgqcgscwafssvgalegq
lkkktgkllnlspqnlvdcvsendgcgggymtnafqyvqknrgidsedaypyvgqeescm
ynptgkaakcrgyreipegnekalkravarvgpvsvaidasltsfqfyskgvyydescns
dnlnhavlavgygiqkgnkhwiiknswgenwgnkgyilmarnknnacgianlasfpkm

Timeline for d7pckd_:

• d7pckd_ first appeared (with stable ids) in SCOP 1.55
  
• d7pckd_ appears in SCOP 1.75
  
• d7pckd_ appears in SCOPe 2.02
  
• d7pckd_ appears in the current release, SCOPe 2.08