SCOP 1.75: Domain d1ayva_: 1ayv A:

Lineage for d1ayva_ (1ayv A:)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (22 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (25 proteins)

6. Protein (Pro)cathepsin K [54028] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [54029] (31 PDB entries)
   Uniprot P43235 116-329
   Uniprot P43235 115-329
   Uniprot P43235 116-329 ! Uniprot P43235 115-329

8. Domain d1ayva_: 1ayv A: [37072]
   complexed with in6

Details for d1ayva_

PDB Entry: 1ayv, 2.3 Å

PDB Description: crystal structure of cysteine protease human cathepsin k in complex with a covalent thiazolhydrazide inhibitor

PDB Compounds: (A:) cathepsin k

SCOP Domain Sequences for d1ayva_:

Sequence; same for both SEQRES and ATOM records:

>d1ayva_ d.3.1.1 (A:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

Timeline for d1ayva_:

• d1ayva_ first appeared (with stable ids) in SCOP 1.55, called d1ayv__
  
• d1ayva_ appears in SCOP 1.73
  
• d1ayva_ appears in SCOPe 2.01
  
• d1ayva_ appears in the current release, SCOPe 2.08