SCOP 1.71: Domain d1cs8a_: 1cs8 A:

Lineage for d1cs8a_ (1cs8 A:)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (12 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (23 proteins)

6. Protein (Pro)cathepsin L [54026] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [54027] (4 PDB entries)

8. Domain d1cs8a_: 1cs8 A: [37065]
   contains propeptide
   mutant

Details for d1cs8a_

PDB Entry: 1cs8, 1.8 Å

PDB Description: crystal structure of procathepsin l

SCOP Domain Sequences for d1cs8a_:

Sequence; same for both SEQRES and ATOM records:

>d1cs8a_ d.3.1.1 (A:) (Pro)cathepsin L {Human (Homo sapiens)}
sltfdhsleaqwtkwkamhnrlygmneegwrravweknmkmielhnqeyregkhsftmam
nafgdmtseefrqvmngfqnrkprkgkvfqeplfyeaprsvdwrekgyvtpvknqgqcgs
cwafsatgalegqmfrktgrlislseqnlvdcsgpqgnegcngglmdyafqyvqdnggld
seesypyeateesckynpkysvandagfvdipkqekalmkavatvgpisvaidaghesfl
fykegiyfepdcssedmdhgvlvvgygfestesdnnkywlvknswgeewgmggyvkmakd
rrnhcgiasaasyptv

Timeline for d1cs8a_:

• d1cs8a_ first appeared (with stable ids) in SCOP 1.55
  
• d1cs8a_ appears in SCOP 1.69
  
• d1cs8a_ appears in SCOP 1.73
  
• d1cs8a_ appears in the current release, SCOPe 2.08