SCOPe 2.08: Domain d6mj5b2: 6mj5 B:351-607

Lineage for d6mj5b2 (6mj5 B:351-607)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.136: Phospholipase D/nuclease [56023] (1 superfamily)
   beta-alpha-beta-alpha-beta-alpha-beta(4)-alpha; mixed sheet: order 1765234

4. Superfamily d.136.1: Phospholipase D/nuclease [56024] (6 families)

5. Family d.136.1.3: Tyrosyl-DNA phosphodiesterase TDP1 [69815] (2 proteins)

6. Protein Tyrosyl-DNA phosphodiesterase TDP1 [69816] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69817] (36 PDB entries)

8. Domain d6mj5b2: 6mj5 B:351-607 [370629]
   automated match to d1qzqa2
   protein/DNA complex; complexed with edo, jta

Details for d6mj5b2

PDB Entry: 6mj5, 1.85 Å

PDB Description: crystal structure of tdp1 catalytic domain in complex with compound xz519

PDB Compounds: (B:) tyrosyl-DNA phosphodiesterase 1

SCOPe Domain Sequences for d6mj5b2:

Sequence, based on SEQRES records:

>d6mj5b2 d.136.1.3 (B:351-607) Tyrosyl-DNA phosphodiesterase TDP1 {Human (Homo sapiens) [TaxId: 9606]}
nvyligstpgrfqgsqkdnwghfrlkkllkdhassmpnaeswpvvgqfssvgslgadesk
wlcsefkesmltlgkesktpgkssvplyliypsvenvrtslegypaggslpysiqtaekq
nwlhsyfhkwsaetsgrsnamphiktymrpspdfskiawflvtsanlskaawgalekngt
qlmirsyelgvlflpsafgldsfkvkqkffagsqepmatfpvpydlppelygskdrpwiw
nipyvkapdthgnmwvp

Sequence, based on observed residues (ATOM records):

>d6mj5b2 d.136.1.3 (B:351-607) Tyrosyl-DNA phosphodiesterase TDP1 {Human (Homo sapiens) [TaxId: 9606]}
nvyligstpgrfqgsqkdnwghfrlkkllkdhassmpnaeswpvvgqfssvgslgadesk
wlcsefkesmltlgkesssvplyliypsvenvrtslegypaggslpysiqtaekqnwlhs
yfhkwsaetsgrsnamphiktymrpspdfskiawflvtsanlskaawgalekngtqlmir
syelgvlflpsafgldsfkvkqkffapmatfpvpydlppelygskdrpwiwnipyvkapd
thgnmwvp

Timeline for d6mj5b2:

• d6mj5b2 first appeared in SCOPe 2.07