Lineage for d6hk4b_ (6hk4 B:)

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (2 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  7. Species Human (Homo sapiens) [TaxId:9606] [69824] (56 PDB entries)
    Uniprot P49841 35-383 ! Uniprot P49841 35-384
  8. Domain d6hk4b_: 6hk4 B: [370256]
    automated match to d1gngb_
    complexed with dms, g8e, gol, mli

Details for d6hk4b_

PDB Entry: 6hk4 (more details), 2.5 Å

PDB Description: crystal structure of gsk-3b in complex with pyrazine inhibitor c22
PDB Compounds: (B:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d6hk4b_:

Sequence; same for both SEQRES and ATOM records: (download)

>d6hk4b_ d.144.1.7 (B:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
skvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfk
nrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlp
viyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnv
syicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlg
tptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltplea
cahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

SCOPe Domain Coordinates for d6hk4b_ are not available.

Timeline for d6hk4b_:

Domains from other chains:
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d6hk4a_