Lineage for d6gvaa_ (6gva A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2542927Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  7. 2542928Species Human (Homo sapiens) [TaxId:9606] [88856] (402 PDB entries)
    Uniprot P24941
  8. 3068329Domain d6gvaa_: 6gva A: [368391]
    Other proteins in same PDB: d6gvab1, d6gvab2
    automated match to d1gy3a_
    complexed with br, cl, edo, fcq, pg4, pge, sgm

Details for d6gvaa_

PDB Entry: 6gva (more details), 2.15 Å

PDB Description: cdk2/cyclin a2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor lgr4455
PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d6gvaa_:

Sequence, based on SEQRES records: (download)

>d6gvaa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvt

Sequence, based on observed residues (ATOM records): (download)

>d6gvaa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtegvpstaireisllkelnhpn
ivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshr
vlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyyst
avdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpk
warqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvt

SCOPe Domain Coordinates for d6gvaa_:

Click to download the PDB-style file with coordinates for d6gvaa_.
(The format of our PDB-style files is described here.)

Timeline for d6gvaa_:

  • d6gvaa_ appears in periodic updates to SCOPe 2.07 starting on 2019-05-02