SCOPe 2.08: Domain d6edla_: 6edl A:

Lineage for d6edla_ (6edl A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d6edla_: 6edl A: [368355]
   automated match to d4foda_
   complexed with j4m

Details for d6edla_

PDB Entry: 6edl, 2.8 Å

PDB Description: halk in complex with compound 1 (s)-n-(1-(2,4-difluorophenyl)ethyl)-3- (3-methyl-1h-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine

PDB Compounds: (A:) ALK tyrosine kinase receptor

SCOPe Domain Sequences for d6edla_:

Sequence, based on SEQRES records:

>d6edla_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktl
pevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretr
prpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfg
mardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympyps
ksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdv
intalpi

Sequence, based on observed residues (ATOM records):

>d6edla_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgevyegqvssplqvavktlpevcseqde
ldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpssl
amldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfcamlpvkwmp
peafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgp
vyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpi

Timeline for d6edla_:

• d6edla_ first appeared in SCOPe 2.07