SCOPe 2.08: Domain d6h18a1: 6h18 A:2-533

Lineage for d6h18a1 (6h18 A:2-533)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (43 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
   automatically mapped to Pfam PF00135

6. Protein automated matches [190065] (7 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186857] (44 PDB entries)

8. Domain d6h18a1: 6h18 A:2-533 [366759]
   Other proteins in same PDB: d6h18a2
   automated match to d1f6wa_
   complexed with act, sgb, zn

Details for d6h18a1

PDB Entry: 6h18, 1.85 Å

PDB Description: crystal structure of sarin surrogate nimp inhibited recombinant human bile salt activated lipase

PDB Compounds: (A:) Bile salt-activated lipase

SCOPe Domain Sequences for d6h18a1:

Sequence, based on SEQRES records:

>d6h18a1 c.69.1.1 (A:2-533) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klgavyteggfvegvnkklgllgdsvdifkgipfaaptkalenpqphpgwqgtlkaknfk
krclqatitqdstygdedclylniwvpqgrkqvsrdlpvmiwiyggaflmgsghganfln
nylydgeeiatrgnvivvtfnyrvgplgflstgdanlpgnyglrdqhmaiawvkrniaaf
ggdpdnitlfgesaggasvslqtlspynkglirraisqsgvalspwviqknplfwakkva
ekvgcpvgdaarmaqclkvtdpraltlaykvplagleypmlhyvgfvpvidgdfipddpi
nlyanaadidyiagtnnmdghifasidmpainkgnkkvteedfyklvseftitkglrgak
ttfdvyteswaqdpsqenkkktvvdfetdvlflvpteialaqhranaksaktyaylfshp
srmpvypkwvgadhaddiqyvfgkpfatptgyrpqdrtvskamiaywtnfaktgdpnmgd
savpthwepyttensgyleitkkmgsssmkrslrtnflrywtltylalptvt

Sequence, based on observed residues (ATOM records):

>d6h18a1 c.69.1.1 (A:2-533) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klgavyteggfvegvnkklgllgdsvdifkgipfaaptkalenpqphpgwqgtlkaknfk
krclqatitqdstygdedclylniwvpqgrkqvsrdlpvmiwiyggaflmgsghganfln
nylydgeeiatrgnvivvtfnyrvgplgflstgdanlpgnyglrdqhmaiawvkrniaaf
ggdpdnitlfgesaggasvslqtlspynkglirraisqsgvalspwviqknplfwakkva
ekvgcpvgdaarmaqclkvtdpraltlaykvplagleypmlhyvgfvpvidgdfipddpi
nlyanaadidyiagtnnmdghifasidmpainkgnkkvteedfyklvseftitkglrgak
ttfdvyteswaqdpsqenkkktvvdfetdvlflvpteialaqhranaksaktyaylfshp
adhaddiqyvfgkpfatptgyrpqdrtvskamiaywtnfaktgdpnmgdsavpthwepyt
tensgyleitkkmgsssmkrslrtnflrywtltylalptvt

Timeline for d6h18a1:

• d6h18a1 first appeared in SCOPe 2.07