SCOPe 2.08: Domain d5ovfa_: 5ovf A:

Lineage for d5ovfa_ (5ovf A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.117: Ras GEF [48365] (1 superfamily)
   multihelical

4. Superfamily a.117.1: Ras GEF [48366] (1 family)

5. Family a.117.1.1: Ras GEF [48367] (2 proteins)

6. Protein Son of sevenless protein homolog 1 (sos-1) [48368] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48369] (60 PDB entries)
   Uniprot Q07889 189-1046

8. Domain d5ovfa_: 5ovf A: [364763]
   automated match to d1nvus_
   complexed with awt, edo

Details for d5ovfa_

PDB Entry: 5ovf, 2.01 Å

PDB Description: ras guanine nucleotide exchange factor sos1 (rem-cdc25) in complex with small molecule inhibitor compound 17

PDB Compounds: (A:) Son of sevenless homolog 1

SCOPe Domain Sequences for d5ovfa_:

Sequence, based on SEQRES records:

>d5ovfa_ a.117.1.1 (A:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
gamaeeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmya
dpnfvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrk
eyiqpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqr
kkiardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyrav
qpselvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieil
qvfqelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylakl
rsinppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpy
clrvesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspg
vrpsnp

Sequence, based on observed residues (ATOM records):

>d5ovfa_ a.117.1.1 (A:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
gamaeeqmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvr
tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
fqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtked
keinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvle
vvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiy
ltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffen
lnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp

Timeline for d5ovfa_:

• d5ovfa_ first appeared in SCOPe 2.07