Lineage for d6epos_ (6epo S:)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2338409Fold a.117: Ras GEF [48365] (1 superfamily)
    multihelical
  4. 2338410Superfamily a.117.1: Ras GEF [48366] (1 family) (S)
  5. 2338411Family a.117.1.1: Ras GEF [48367] (2 proteins)
  6. 2338412Protein Son of sevenless protein homolog 1 (sos-1) [48368] (1 species)
  7. 2338413Species Human (Homo sapiens) [TaxId:9606] [48369] (60 PDB entries)
    Uniprot Q07889 189-1046
  8. 2338469Domain d6epos_: 6epo S: [364425]
    Other proteins in same PDB: d6epor_
    automated match to d1nvus_
    complexed with bpw, gol

Details for d6epos_

PDB Entry: 6epo (more details), 2.4 Å

PDB Description: ras guanine exchange factor sos1 (rem-cdc25) in complex with kras(g12c) and fragment screening hit f3
PDB Compounds: (S:) Son of sevenless homolog 1

SCOPe Domain Sequences for d6epos_:

Sequence, based on SEQRES records: (download)

>d6epos_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqp
vqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiar
dngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpsel
vgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqe
lnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinp
pcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrve
sdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn
pr

Sequence, based on observed residues (ATOM records): (download)

>d6epos_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepsaelkrfrkeyiqpvqlrvlnvcrhwvehhf
ydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiaitfqsspptvewhisrpg
hietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspnllkmirhtt
nltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamnsspvyrldht
feqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilkteegnpevlk
rhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgnsmekeftdyl
fnksleieprnpkplprfpkkysyplkspgvrpsnpr

SCOPe Domain Coordinates for d6epos_:

Click to download the PDB-style file with coordinates for d6epos_.
(The format of our PDB-style files is described here.)

Timeline for d6epos_: