SCOPe 2.08: Domain d6epns_: 6epn S:

Lineage for d6epns_ (6epn S:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.117: Ras GEF [48365] (1 superfamily)
   multihelical

4. Superfamily a.117.1: Ras GEF [48366] (1 family)

5. Family a.117.1.1: Ras GEF [48367] (2 proteins)

6. Protein Son of sevenless protein homolog 1 (sos-1) [48368] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48369] (60 PDB entries)
   Uniprot Q07889 189-1046

8. Domain d6epns_: 6epn S: [364402]
   Other proteins in same PDB: d6epnr_
   automated match to d1nvus_
   complexed with bq2, dms, gol

Details for d6epns_

PDB Entry: 6epn, 2.5 Å

PDB Description: ras guanine exchange factor sos1 (rem-cdc25) in complex with kras(g12c) and fragment screening hit f2

PDB Compounds: (S:) Son of sevenless homolog 1

SCOPe Domain Sequences for d6epns_:

Sequence, based on SEQRES records:

>d6epns_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqp
vqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiar
dngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpsel
vgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqe
lnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinp
pcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrve
sdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn
pr

Sequence, based on observed residues (ATOM records):

>d6epns_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepteasaelkrfrkeyiqpvqlrvlnvcrhw
vehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiaitfqsspptvewh
isrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspnllkm
irhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamnsspvy
rldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilkteegn
pevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgnsmeke
ftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr

Timeline for d6epns_:

• d6epns_ first appeared in SCOPe 2.07