Lineage for d6epps_ (6epp S:)

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2725336Fold a.117: Ras GEF [48365] (1 superfamily)
    multihelical
  4. 2725337Superfamily a.117.1: Ras GEF [48366] (1 family) (S)
  5. 2725338Family a.117.1.1: Ras GEF [48367] (2 proteins)
  6. 2725339Protein Son of sevenless protein homolog 1 (sos-1) [48368] (1 species)
  7. 2725340Species Human (Homo sapiens) [TaxId:9606] [48369] (60 PDB entries)
    Uniprot Q07889 189-1046
  8. 2725397Domain d6epps_: 6epp S: [364393]
    Other proteins in same PDB: d6eppr_
    automated match to d1nvus_
    complexed with boq, gol

Details for d6epps_

PDB Entry: 6epp (more details), 2.4 Å

PDB Description: ras guanine exchange factor sos1 (rem-cdc25) in complex with kras(g12c) and fragment screening hit f4
PDB Compounds: (S:) Son of sevenless homolog 1

SCOPe Domain Sequences for d6epps_:

Sequence, based on SEQRES records: (download)

>d6epps_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqp
vqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiar
dngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpsel
vgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqe
lnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinp
pcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrve
sdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn
pr

Sequence, based on observed residues (ATOM records): (download)

>d6epps_ a.117.1.1 (S:) Son of sevenless protein homolog 1 (sos-1) {Human (Homo sapiens) [TaxId: 9606]}
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepsaelkrfrkeyiqpvqlrvlnvcrhwveh
hfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiaitfqsspptvewhisr
pghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspnllkmirh
ttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamnsspvyrld
htfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilkteegnpev
lkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgnsmekeftd
ylfnksleieprnpkplprfpkkysyplkspgvrpsnpr

SCOPe Domain Coordinates for d6epps_:

Click to download the PDB-style file with coordinates for d6epps_.
(The format of our PDB-style files is described here.)

Timeline for d6epps_: