SCOPe 2.08: Domain d6huba_: 6hub A:

Lineage for d6huba_ (6hub A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.4: Proteasome subunits [56251] (4 proteins)

6. Protein Proteasome alpha subunit (non-catalytic) [56255] (10 species)
   contains an extension to the common fold at the N-terminus

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56257] (240 PDB entries)
   The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)

8. Domain d6huba_: 6hub A: [363385]
   Other proteins in same PDB: d6hubb_, d6hubc2, d6hubh_, d6hubi_, d6hubj_, d6hubk_, d6hubl_, d6hubm_, d6hubn_, d6hubq2, d6hubv_, d6hubw_, d6hubx_, d6huby_, d6hubz_
   automated match to d1rypb_
   complexed with cl, grw, mg, so4

Details for d6huba_

PDB Entry: 6hub, 2.9 Å

PDB Description: yeast 20s proteasome with human beta2c (s171g) in complex with 16

PDB Compounds: (A:) Proteasome subunit alpha type-2

SCOPe Domain Sequences for d6huba_:

Sequence, based on SEQRES records:

>d6huba_ d.153.1.4 (A:) Proteasome alpha subunit (non-catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mtdrysfslttfspsgklgqidyaltavkqgvtslgikatngvviatekksssplamset
lskvslltpdigavysgmgpdyrvlvdksrkvahtsykriygeypptkllvsevakimqe
atqsggvrpfgvslliaghdefngfslyqvdpsgsyfpwkataigkgsvaaktflekrwn
deleledaihialltlkesvegefngdtielaiigdenpdllgytgiptdkgprfrklts
qeindrleal

Sequence, based on observed residues (ATOM records):

>d6huba_ d.153.1.4 (A:) Proteasome alpha subunit (non-catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mtdrysfslttfspsgklgqidyaltavkqgvtslgikatngvviatekksssplamset
lskvslltpdigavysgmgpdyrvlvdksrkvahtsykriygeypptkllvsevakimqe
atqsggvrpfgvslliaghdefngfslyqvdpsgsyfpwkataigkgsvaaktflekrwn
deleledaihialltlkesvegefngdtielaiigdenpdkgprfrkltsqeindrleal

Timeline for d6huba_:

• d6huba_ first appeared in SCOPe 2.07