SCOPe 2.07: Domain d6cgca_: 6cgc A:

Lineage for d6cgca_ (6cgc A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein automated matches [190085] (58 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186828] (33 PDB entries)

8. Domain d6cgca_: 6cgc A: [362103]
   automated match to d1fdsa_
   complexed with f0a, nap

Details for d6cgca_

PDB Entry: 6cgc, 2.1 Å

PDB Description: crystal structure of human 17beta-hsd type 1 in ternary complex with 2-meo-cc-156 and nadp+

PDB Compounds: (A:) Estradiol 17-beta-dehydrogenase 1

SCOPe Domain Sequences for d6cgca_:

Sequence, based on SEQRES records:

>d6cgca_ c.2.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfg

Sequence, based on observed residues (ATOM records):

>d6cgca_ c.2.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalrap
kptlryftterflpllrmrlddpsgsnyvtamhrevfg

Timeline for d6cgca_:

• d6cgca_ is new in SCOPe 2.07-stable
  
• d6cgca_ appears in the current release, SCOPe 2.08