SCOPe 2.08: Domain d6hmma_: 6hmm A:

Lineage for d6hmma_ (6hmm A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.50: Macro domain-like [52948] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

4. Superfamily c.50.1: Macro domain-like [52949] (4 families)

5. Family c.50.1.3: Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain-like [310642] (2 proteins)
   Pfam PF05028
   Contains N- and C-terminal extensions to macrodomain, including Tyr clasp, discussed in PubMed 22609859

6. Protein Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain [310785] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [324080] (19 PDB entries)

8. Domain d6hmma_: 6hmm A: [360249]
   automated match to d4fc2d_
   complexed with 7jb, dms, gol, so4

Details for d6hmma_

PDB Entry: 6hmm, 1.9 Å

PDB Description: polyadpribosyl glycohydrolase in complex with pdd00013907

PDB Compounds: (A:) Poly(ADP-ribose) glycohydrolase

SCOPe Domain Sequences for d6hmma_:

Sequence, based on SEQRES records:

>d6hmma_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynvayskkwd
ftalidfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeq
iasllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaa
aptglvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvts
aglvqeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgs
erddwqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgn
wgcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvy
klllryyneecrncstpgpdiklypfiyhavesc

Sequence, based on observed residues (ATOM records):

>d6hmma_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvtagsrweliqtallnkftrpqnlkdailkynvayskkwdftalidf
wdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqiasllan
affctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaaaptglvt
ftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsaglvqee
irflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgserddwqr
rcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnwgcgafg
gdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyklllryy
neecrncstpgpdiklypfiyhavesc

Timeline for d6hmma_:

• d6hmma_ first appeared in SCOPe 2.07