SCOPe 2.08: Domain d6e41b1: 6e41 B:15-401

Lineage for d6e41b1 (6e41 B:15-401)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
   multihelical; bundle, contains interrupted helices

4. Superfamily a.266.1: Indolic compounds 2,3-dioxygenase-like [140959] (3 families)
   contains heme-dependent enzymes

5. Family a.266.1.2: Indoleamine 2,3-dioxygenase-like [140963] (3 proteins)
   Pfam PF01231; contains extra N-terminal all-alpha subdomain of similar fold to the GST C-terminal domain (47615)

6. Protein automated matches [190585] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187592] (52 PDB entries)

8. Domain d6e41b1: 6e41 B:15-401 [360221]
   Other proteins in same PDB: d6e41a2, d6e41b2, d6e41c2, d6e41d2
   automated match to d5wmxb_
   complexed with hem, hqs

Details for d6e41b1

PDB Entry: 6e41, 2.29 Å

PDB Description: crystal structure of human indoleamine 2,3-dioxygenase 1 (ido1) in complex with ferric heme and an epacadostat analog

PDB Compounds: (B:) Indoleamine 2,3-dioxygenase 1

SCOPe Domain Sequences for d6e41b1:

Sequence, based on SEQRES records:

>d6e41b1 a.266.1.2 (B:15-401) automated matches {Human (Homo sapiens) [TaxId: 9606]}
yhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdhk
sqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaalelppilvyadcvlanw
kkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqerd
tllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfwe
dpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesnp
svrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsedpskl
eakgtggtdlmnflktvrstteksllk

Sequence, based on observed residues (ATOM records):

>d6e41b1 a.266.1.2 (B:15-401) automated matches {Human (Homo sapiens) [TaxId: 9606]}
yhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhltdhk
sqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlsaalelppilvyadcvlanw
kkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmqerd
tllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyegfwe
dpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcslesnp
svrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqkleakgtggtdlmn
flktvrstteksllk

Timeline for d6e41b1:

• d6e41b1 first appeared in SCOPe 2.07