SCOPe 2.08: Domain d6cmra3: 6cmr A:219-528

Lineage for d6cmra3 (6cmr A:219-528)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.0: automated matches [191381] (1 protein)
   not a true family

6. Protein automated matches [190475] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187400] (140 PDB entries)

8. Domain d6cmra3: 6cmr A:219-528 [360151]
   Other proteins in same PDB: d6cmra1, d6cmra2
   automated match to d2b3oa3
   complexed with 5od; mutant

Details for d6cmra3

PDB Entry: 6cmr, 2.21 Å

PDB Description: closed structure of active shp2 mutant e76d bound to shp099 inhibitor

PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d6cmra3:

Sequence, based on SEQRES records:

>d6cmra3 c.45.1.0 (A:219-528) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietlqrr

Sequence, based on observed residues (ATOM records):

>d6cmra3 c.45.1.0 (A:219-528) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenknknryknilpfdh
trvvlhsdyinaniimpekksyiatqgclqntvndfwrmvfqensrvivmttkevergks
kcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpd
hgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvd
cdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrr

Timeline for d6cmra3:

• d6cmra3 first appeared in SCOPe 2.07