SCOPe 2.08: Domain d6cmpb3: 6cmp B:219-527

Lineage for d6cmpb3 (6cmp B:219-527)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.0: automated matches [191381] (1 protein)
   not a true family

6. Protein automated matches [190475] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187400] (140 PDB entries)

8. Domain d6cmpb3: 6cmp B:219-527 [360140]
   Other proteins in same PDB: d6cmpa1, d6cmpa2, d6cmpb1, d6cmpb2
   automated match to d2b3oa3
   mutant

Details for d6cmpb3

PDB Entry: 6cmp, 1.8 Å

PDB Description: closed structure of inactive shp2 mutant c459e

PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d6cmpb3:

Sequence, based on SEQRES records:

>d6cmpb3 c.45.1.0 (B:219-527) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
esagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietlqr

Sequence, based on observed residues (ATOM records):

>d6cmpb3 c.45.1.0 (B:219-527) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskqgfweefetlqqqeckllysrkegqrqenknknryknilpfdh
trvvlhdgdpnepvsdyinaniimpefkksyiatqgclqntvndfwrmvfqensrvivmt
tkkcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtw
pdhgvpsdpggvldfleevhhkqesimdagpvvvhesagigrtgtfividilidiirekg
vdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqr

Timeline for d6cmpb3:

• d6cmpb3 first appeared in SCOPe 2.07