SCOPe 2.08: Domain d6bb0a2: 6bb0 A:160-331

Lineage for d6bb0a2 (6bb0 A:160-331)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein Lactate dehydrogenase [56339] (20 species)

7. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (39 PDB entries)

8. Domain d6bb0a2: 6bb0 A:160-331 [359302]
   Other proteins in same PDB: d6bb0a1, d6bb0b1, d6bb0c1, d6bb0d1
   automated match to d1i10d2
   complexed with d3s, epe, lac, nad, so4

Details for d6bb0a2

PDB Entry: 6bb0, 1.95 Å

PDB Description: lactate dehydrogenase in complex with inhibitor (r)-3-((2- chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6- (thiophen-3-yl)-5,6-dihydro-2h-pyran-2-one

PDB Compounds: (A:) L-lactate dehydrogenase A chain

SCOPe Domain Sequences for d6bb0a2:

Sequence; same for both SEQRES and ATOM records:

>d6bb0a2 d.162.1.1 (A:160-331) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
sgcnldsarfrylmgerlgvhplschgwvlgehgdssvpvwsgmnvagvslktlhpdlgt
dkdkeqwkevhkqvvesayeviklkgytswaiglsvadlaesimknlrrvhpvstmikgl
ygikddvflsvpcilgqngisdlvkvtltseeearlkksadtlwgiqkelqf

Timeline for d6bb0a2:

• d6bb0a2 first appeared in SCOPe 2.07