SCOPe 2.07: Domain d6bb1d2: 6bb1 D:160-331

Lineage for d6bb1d2 (6bb1 D:160-331)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein Lactate dehydrogenase [56339] (20 species)

7. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (38 PDB entries)

8. Domain d6bb1d2: 6bb1 D:160-331 [359121]
   Other proteins in same PDB: d6bb1a1, d6bb1b1, d6bb1c1, d6bb1d1, d6bb1e1, d6bb1f1, d6bb1g1, d6bb1h1
   automated match to d1i10d2
   complexed with d3j, lac, nad, so4

Details for d6bb1d2

PDB Entry: 6bb1, 2.3 Å

PDB Description: lactate dehydrogenase in complex with inhibitor (r)-5-((2- chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)- 2,3-dihydro-[2,2'-bipyridin]-6(1h)-one

PDB Compounds: (D:) L-lactate dehydrogenase A chain

SCOPe Domain Sequences for d6bb1d2:

Sequence; same for both SEQRES and ATOM records:

>d6bb1d2 d.162.1.1 (D:160-331) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
sgcnldsarfrylmgerlgvhplschgwvlgehgdssvpvwsgmnvagvslktlhpdlgt
dkdkeqwkevhkqvvesayeviklkgytswaiglsvadlaesimknlrrvhpvstmikgl
ygikddvflsvpcilgqngisdlvkvtltseeearlkksadtlwgiqkelqf

Timeline for d6bb1d2:

• d6bb1d2 is new in SCOPe 2.07-stable
  
• d6bb1d2 appears in the current release, SCOPe 2.08