SCOPe 2.08: Domain d5zxba_: 5zxb A:

Lineage for d5zxba_ (5zxb A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111201] (11 PDB entries)
   Uniprot Q07912 117-389

8. Domain d5zxba_: 5zxb A: [358135]
   automated match to d4ewha_
   complexed with 9ko

Details for d5zxba_

PDB Entry: 5zxb, 2.2 Å

PDB Description: crystal structure of ack1 with compound 10d

PDB Compounds: (A:) Activated CDC42 kinase 1

SCOPe Domain Sequences for d5zxba_:

Sequence, based on SEQRES records:

>d5zxba_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdvlsqpeamddfir
evnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqv
aegmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfaw
capeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedc
pqdiynvmvqcwahkpedrptfvalrdflleaq

Sequence, based on observed residues (ATOM records):

>d5zxba_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgvvrrgewdapsgktvsvavkclamddfirevnamhsldhrn
lirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqvaegmgyleskrf
ihrdlaarnlllatrdlvkigdfpfawcapeslktrtfshasdtwmfgvtlwemftygqe
pwiglngsqilhkidkegerlprpedcpqdiynvmvqcwahkpedrptfvalrdflleaq

Timeline for d5zxba_:

• d5zxba_ first appeared in SCOPe 2.07