SCOPe 2.08: Domain d6c56b1: 6c56 B:1-295

Lineage for d6c56b1 (6c56 B:1-295)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein Geranylgeranyl pyrophosphate synthetase [158813] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [158814] (5 PDB entries)
   Uniprot O95749 6-296

8. Domain d6c56b1: 6c56 B:1-295 [357094]
   Other proteins in same PDB: d6c56a2, d6c56b2
   automated match to d2q80a1
   complexed with vt0; mutant

Details for d6c56b1

PDB Entry: 6c56, 2.8 Å

PDB Description: crystal structure of mutant human geranylgeranyl pyrophosphate synthase (y246d) in its apo form

PDB Compounds: (B:) Geranylgeranyl pyrophosphate synthase

SCOPe Domain Sequences for d6c56b1:

Sequence, based on SEQRES records:

>d6c56b1 a.128.1.1 (B:1-295) Geranylgeranyl pyrophosphate synthetase {Human (Homo sapiens) [TaxId: 9606]}
mektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnas
lliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqll
elhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntl
glffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrten
idikkdcvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

Sequence, based on observed residues (ATOM records):

>d6c56b1 a.128.1.1 (B:1-295) Geranylgeranyl pyrophosphate synthetase {Human (Homo sapiens) [TaxId: 9606]}
mektqetvqrillepykyllqlpgrtklsqafnhwlkvpedklqiiievtemlhnaslli
ddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelh
qgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglf
fqirddyanlhskesfcedltegkfsfptihaiwskdcvhyledvgsfeytrntlkelea
kaykqidarggnpelvalvkhlskmf

Timeline for d6c56b1:

• d6c56b1 first appeared in SCOPe 2.07