SCOPe 2.07: Domain d6adgc_: 6adg C:

Lineage for d6adgc_ (6adg C:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein automated matches [190072] (22 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189131] (10 PDB entries)

8. Domain d6adgc_: 6adg C: [356984]
   automated match to d1t0la_
   complexed with 9uo, mg, ndp

Details for d6adgc_

PDB Entry: 6adg, 3 Å

PDB Description: crystal structures of idh1 r132h in complex with ag-881

PDB Compounds: (C:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d6adgc_:

Sequence, based on SEQRES records:

>d6adgc_ c.77.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqak

Sequence, based on observed residues (ATOM records):

>d6adgc_ c.77.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcangtirnilggtvfreaiickniprlvsgwvkpiiighhaygdqyratd
fvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdksiedfahssfqmalsk
gwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyehrliddmvaqamkseg
gfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgktveaeaahgtvtrhyrmyqkgq
etstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtkdlaacikgl
pnvqrsdylntfefmdklgenlkiklaqak

Timeline for d6adgc_:

• d6adgc_ is new in SCOPe 2.07-stable
  
• d6adgc_ appears in the current release, SCOPe 2.08