SCOPe 2.05: Domain d3ecac_: 3eca C:

Lineage for d3ecac_ (3eca C:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.88: Glutaminase/Asparaginase [53773] (1 superfamily)
   consists of two non-similar alpha/beta domains, 3 layers (a/b/a) each
   Domain 1 has mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest; left-handed crossover connection between strands 4 and 5
   Domain 2 has parallel beta-sheet of 4 strands, order 1234

4. Superfamily c.88.1: Glutaminase/Asparaginase [53774] (2 families)

5. Family c.88.1.1: Glutaminase/Asparaginase [53775] (4 proteins)
   automatically mapped to Pfam PF00710

6. Protein Asparaginase type II [53776] (4 species)

7. Species Escherichia coli [TaxId:562] [53777] (7 PDB entries)

8. Domain d3ecac_: 3eca C: [35556]
   complexed with asp

Details for d3ecac_

PDB Entry: 3eca, 2.4 Å

PDB Description: crystal structure of escherichia coli l-asparaginase, an enzyme used in cancer therapy (elspar)

PDB Compounds: (C:) asparaginase type II

SCOPe Domain Sequences for d3ecac_:

Sequence; same for both SEQRES and ATOM records:

>d3ecac_ c.88.1.1 (C:) Asparaginase type II {Escherichia coli [TaxId: 562]}
lpnitilatggtiagggdsatksnytvgkvgvenlvnavpqlkdianvkgeqvvnigsqd
mndnvwltlakkintdcdktdgfvithgtdtmeetayfldltvkcdkpvvmvgamrpsts
msadgpfnlynavvtaadkasanrgvlvvmndtvldgrdvtktnttdvatfksvnygplg
yihngkidyqrtparkhtsdtpfdvsklnelpkvgivynyanasdlpakalvdagydgiv
sagvgngnlyksvfdtlataaktgtavvrssrvptgattqdaevddakygfvasgtlnpq
karvllqlaltqtkdpqqiqqifnqy

Timeline for d3ecac_:

• d3ecac_ first appeared (with stable ids) in SCOP 1.55
  
• d3ecac_ appears in SCOPe 2.04
  
• d3ecac_ appears in SCOPe 2.06
  
• d3ecac_ appears in the current release, SCOPe 2.08