Lineage for d6bl1a1 (6bl1 A:3-414)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2479470Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 2479471Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families) (S)
    the constituent families form similar dimers
  5. 2479472Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
    the active site is between the two identical subunits
  6. 2479566Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)
  7. 2479567Species Human (Homo sapiens) [TaxId:9606] [110715] (31 PDB entries)
    Uniprot O75874
  8. 3055295Domain d6bl1a1: 6bl1 A:3-414 [355357]
    Other proteins in same PDB: d6bl1a2, d6bl1b2, d6bl1c2
    automated match to d1t0la_
    complexed with ca, dwg, ict

Details for d6bl1a1

PDB Entry: 6bl1 (more details), 2.02 Å

PDB Description: novel modes of inhibition of wild-type idh1: direct covalent modification of his315 with cmpd13
PDB Compounds: (A:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d6bl1a1:

Sequence; same for both SEQRES and ATOM records: (download)

>d6bl1a1 c.77.1.1 (A:3-414) NADP-dependent isocitrate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d6bl1a1:

Click to download the PDB-style file with coordinates for d6bl1a1.
(The format of our PDB-style files is described here.)

Timeline for d6bl1a1:

  • d6bl1a1 is new in SCOPe 2.07-stable