Lineage for d5y25a1 (5y25 A:698-1017)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2543502Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2543503Species Human (Homo sapiens) [TaxId:9606] [82796] (109 PDB entries)
    Uniprot P00533 702-1018
  8. 3055225Domain d5y25a1: 5y25 A:698-1017 [355287]
    Other proteins in same PDB: d5y25a2
    automated match to d4zseb_
    complexed with 8lu; mutant

Details for d5y25a1

PDB Entry: 5y25 (more details), 3.1 Å

PDB Description: egfr kinase domain mutant (t790m/l858r) with covalent ligand ns-062
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5y25a1:

Sequence, based on SEQRES records: (download)

>d5y25a1 d.144.1.7 (A:698-1017) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvp
ikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqpp
ictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnf
yralmdeedmddvvdadeyl

Sequence, based on observed residues (ATOM records): (download)

>d5y25a1 d.144.1.7 (A:698-1017) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikeltspkankeil
deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgravpikwmalesilhriythqsd
vwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidad
srpkfreliiefskmardpqrylviqgdermhlpsptdsnfddvvdadeyl

SCOPe Domain Coordinates for d5y25a1:

Click to download the PDB-style file with coordinates for d5y25a1.
(The format of our PDB-style files is described here.)

Timeline for d5y25a1:

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Domains from same chain:
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d5y25a2