SCOPe 2.08: Domain d6gpld_: 6gpl D:

Lineage for d6gpld_ (6gpl D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein GDP-mannose 4,6-dehydratase [51759] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102135] (7 PDB entries)

8. Domain d6gpld_: 6gpl D: [354954]
   automated match to d1t2aa_
   complexed with bcn, edo, f7e, nap
   has additional subdomain(s) that are not in the common domain

Details for d6gpld_

PDB Entry: 6gpl, 1.76 Å

PDB Description: crystal structure of human gdp-d-mannose 4,6-dehydratase in complex with gdp-4k6d-man

PDB Compounds: (D:) GDP-mannose 4,6 dehydratase

SCOPe Domain Sequences for d6gpld_:

Sequence, based on SEQRES records:

>d6gpld_ c.2.1.2 (D:) GDP-mannose 4,6-dehydratase {Human (Homo sapiens) [TaxId: 9606]}
rnvalitgitgqdgsylaefllekgyevhgivrrsssfntgriehlyknpqahiegnmkl
hygdltdstclvkiinevkpteiynlgaqshvkisfdlaeytadvdgvgtlrlldavktc
glinsvkfyqastselygkvqeipqkettpfyprspygaaklyaywivvnfreaynlfav
ngilfnhesprrganfvtrkisrsvakiylgqlecfslgnldakrdwghakdyveamwlm
lqndepedfviatgevhsvrefveksflhigktivwegknenevgrcketgkvhvtvdlk
yyrptevdflqgdctkakqklnwkprvafdelvremvhadvelmrtnpna

Sequence, based on observed residues (ATOM records):

>d6gpld_ c.2.1.2 (D:) GDP-mannose 4,6-dehydratase {Human (Homo sapiens) [TaxId: 9606]}
rnvalitgitgqdgsylaefllekgyevhgivrrsssfntgriehlynmklhygdltdst
clvkiinevkpteiynlgaqshvkisfdlaeytadvdgvgtlrlldavktcglinsvkfy
qastselygkvqeipqkettpfyprspygaaklyaywivvnfreaynlfavngilfnhes
prrganfvtrkisrsvakiylgqlecfslgnldakrdwghakdyveamwlmlqndepedf
viatgevhsvrefveksflhigktivwegknenevgrcketgkvhvtvdlkyyrptevdf
lqgdctkakqklnwkprvafdelvremvhadvelmrtnpna

Timeline for d6gpld_:

• d6gpld_ first appeared in SCOPe 2.07