SCOPe 2.08: Domain d5utzd_: 5utz D:

Lineage for d5utzd_ (5utz D:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-2 (IL-2) [47301] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47302] (20 PDB entries)

8. Domain d5utzd_: 5utz D: [354618]
   Other proteins in same PDB: d5utzb_, d5utzc1, d5utzc2, d5utzf_, d5utzg1, d5utzg2, d5utzh_, d5utzj_, d5utzk1, d5utzk2, d5utzl1, d5utzl2
   automated match to d1m48b_
   complexed with gol

Details for d5utzd_

PDB Entry: 5utz, 2.75 Å

PDB Description: human il-2/fab complex

PDB Compounds: (D:) interleukin-2

SCOPe Domain Sequences for d5utzd_:

Sequence, based on SEQRES records:

>d5utzd_ a.26.1.2 (D:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
sstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelk
pleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwitf
cqsiistlt

Sequence, based on observed residues (ATOM records):

>d5utzd_ a.26.1.2 (D:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
sstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelk
pleevlnlaqsknfhlrprdlisninvivlelkgtfmceyadetativeflnrwitfcqs
iistlt

Timeline for d5utzd_:

• d5utzd_ first appeared in SCOPe 2.07