SCOPe 2.08: Domain d5w5qb_: 5w5q B:

Lineage for d5w5qb_ (5w5q B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5w5qb_: 5w5q B: [353790]
   automated match to d5ig1b_
   complexed with 9x4

Details for d5w5qb_

PDB Entry: 5w5q, 2.33 Å

PDB Description: map4k4 in complex with inhibitor compound 12 (n3-methyl-10-(3-methyl- 3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5h-5,7- methanobenzo[c]imidazo[1,2-a]azepine-2,3-dicarboxamide)

PDB Compounds: (B:) Mitogen-activated protein kinase kinase kinase kinase 4

SCOPe Domain Sequences for d5w5qb_:

Sequence, based on SEQRES records:

>d5w5qb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
idlsslrdpagifelvevvgngtygqvykgrhvktgqlaaikvmdvtedeeeeikleinm
lkkyshhrniatyygafikksppghddqlwlvmefcgagsitdlvkntkgntlkedwiay
isreilrglahlhihhvihrdikgqnvlltenaevklvdfgvsaqldrtvgrrntfigtp
ywmapeviacdenpdatydyrsdlwscgitaiemaegapplcdmhpmralfliprnpppr
lkskkwskkffsfiegclvknymqrpsteqllkhpfirdqpnerqvriqlkdhidrtrk

Sequence, based on observed residues (ATOM records):

>d5w5qb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
idlsslrdpagifelvevvgnggqvykgrhvktgqlaaikvmdvtedeeeeikleinmlk
kyshhrniatyygafikksppghddqlwlvmefcgagsitdlvkntkgntlkedwiayis
reilrglahlhihhvihrdikgqnvlltenaevklvdfgvsaqldrtvgrrntfigtpyw
mapeviacdenpdatydyrsdlwscgitaiemaegapplcdmhpmralfliprnppprlk
skkwskkffsfiegclvknymqrpsteqllkhpfirdqpnerqvriqlkdhidrtrk

Timeline for d5w5qb_:

• d5w5qb_ first appeared in SCOPe 2.07