Lineage for d5vz6b_ (5vz6 B:)

  1. Root: SCOPe 2.08
  2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)
  3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families) (S)
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
  5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)
  6. Protein HIV-1 reverse transcriptase [56689] (4 species)
  7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (203 PDB entries)
    Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595
  8. Domain d5vz6b_: 5vz6 B: [352995]
    Other proteins in same PDB: d5vz6a2, d5vz6a3
    automated match to d1s1tb_
    complexed with 9tv

Details for d5vz6b_

PDB Entry: 5vz6 (more details), 2.6 Å

PDB Description: hiv reverse transcriptase complexed with (e)-3-(pyrimidin-2-yl)-n-(5- (5,6,7,8-tetrahydronaphthalen-2-yl)-1h-pyrazol-3-yl)acrylamide
PDB Compounds: (B:) HIV Reverse transcriptase

SCOPe Domain Sequences for d5vz6b_:

Sequence, based on SEQRES records: (download)

>d5vz6b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyq

Sequence, based on observed residues (ATOM records): (download)

>d5vz6b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikt
kwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkyta
ftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyv
gsdleigqhrtkieelrqhllrwgltgyelhpdkwtvqpivlpekdswtvndiqklvgkl
nwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskd
liaeiqkqgqgqwtyqiyqepfknlktgkyarhtndvkqlteavqkittesiviwgktpk
fklpiqketwetwwteywqatwipewefvntpplvklwyq

SCOPe Domain Coordinates for d5vz6b_ are not available.

Timeline for d5vz6b_:

Domains from other chains:
(mouse over for more information)
d5vz6a1, d5vz6a2, d5vz6a3