Lineage for d6de4a_ (6de4 A:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2903429Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2903430Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2903431Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 2903757Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2903805Species Human (Homo sapiens) [TaxId:9606] [53607] (80 PDB entries)
  8. 2903894Domain d6de4a_: 6de4 A: [352404]
    automated match to d1kmva_
    complexed with ca, cl, eoh, g6y, gol, ndp, so4

Details for d6de4a_

PDB Entry: 6de4 (more details), 2.41 Å

PDB Description: homo sapiens dihydrofolate reductase complexed with beta-nadph and 3'- [(2r)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'- biphenyl]-4-carboxylic acid
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d6de4a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d6de4a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

SCOPe Domain Coordinates for d6de4a_:

Click to download the PDB-style file with coordinates for d6de4a_.
(The format of our PDB-style files is described here.)

Timeline for d6de4a_: