SCOPe 2.08: Domain d6dava_: 6dav A:

Lineage for d6dava_ (6dav A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (80 PDB entries)

8. Domain d6dava_: 6dav A: [352099]
   automated match to d1mvta_
   complexed with edo, g3v, nap

Details for d6dava_

PDB Entry: 6dav, 1.55 Å

PDB Description: crystal structure of human dhfr complexed with nadp and n10formyltetrahydrofolate

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d6dava_:

Sequence; same for both SEQRES and ATOM records:

>d6dava_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d6dava_:

• d6dava_ first appeared in SCOPe 2.07