SCOPe 2.07: Domain d5xsra2: 5xsr A:136-349

Lineage for d5xsra2 (5xsr A:136-349)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.166: ADP-ribosylation [56398] (1 superfamily)
   unusual fold

4. Superfamily d.166.1: ADP-ribosylation [56399] (8 families)

5. Family d.166.1.0: automated matches [191650] (1 protein)
   not a true family

6. Protein automated matches [191197] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225406] (55 PDB entries)

8. Domain d5xsra2: 5xsr A:136-349 [351542]
   Other proteins in same PDB: d5xsra1
   automated match to d4hhyd2
   complexed with 8ec, so4

Details for d5xsra2

PDB Entry: 5xsr, 2.3 Å

PDB Description: novel orally efficacious inhibitors complexed with parp1

PDB Compounds: (A:) Poly [ADP-ribose] polymerase 1

SCOPe Domain Sequences for d5xsra2:

Sequence, based on SEQRES records:

>d5xsra2 d.166.1.0 (A:136-349) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lktdikvvdrdseeaeiirkyvknthatthnaydlevidifkieregecqrykpfkqlhn
rrllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanychtsqgdpi
glillgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvplgtgis
sgvndtsllyneyivydiaqvnlkyllklkfnfk

Sequence, based on observed residues (ATOM records):

>d5xsra2 d.166.1.0 (A:136-349) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lktdikvvdrdseeaeiirkyvknthaaydlevidifkieregecqrykpfkqlhnrrll
whgsrttnfagilsqglriappeapvtgymfgkgiyfadmvsksanychtsqgdpiglil
lgevalgnmyelkhashisklpkgkhsvkglgkttpdpsanisldgvdvplgtgissgvn
dtsllyneyivydiaqvnlkyllklkfnfk

Timeline for d5xsra2:

• d5xsra2 is new in SCOPe 2.07-stable
  
• d5xsra2 appears in the current release, SCOPe 2.08