SCOPe 2.07: Domain d5xsra1: 5xsr A:1-135

Lineage for d5xsra1 (5xsr A:1-135)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily)
   core: 4 helices: bundle; unusual topology

4. Superfamily a.41.1: Domain of poly(ADP-ribose) polymerase [47587] (2 families)
   duplication: consists of 2 helix-loop-helix structural repeats
   automatically mapped to Pfam PF02877

5. Family a.41.1.0: automated matches [227223] (1 protein)
   not a true family

6. Protein automated matches [226964] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225405] (61 PDB entries)

8. Domain d5xsra1: 5xsr A:1-135 [351541]
   Other proteins in same PDB: d5xsra2
   automated match to d4hhyd1
   complexed with 8ec, so4

Details for d5xsra1

PDB Entry: 5xsr, 2.3 Å

PDB Description: novel orally efficacious inhibitors complexed with parp1

PDB Compounds: (A:) Poly [ADP-ribose] polymerase 1

SCOPe Domain Sequences for d5xsra1:

Sequence, based on SEQRES records:

>d5xsra1 a.41.1.0 (A:1-135) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qgssdsqildlsnrfytliphdfgmkkppllnnadsvqakaemldnlldievaysllrgg
sddsskdpidvnyek

Sequence, based on observed residues (ATOM records):

>d5xsra1 a.41.1.0 (A:1-135) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qgssdsqildlsnrfytliphdfgmkkppllnnadsvqakaemldnlldievaysllrgg
ssskdpidvnyek

Timeline for d5xsra1:

• d5xsra1 is new in SCOPe 2.07-stable
  
• d5xsra1 appears in the current release, SCOPe 2.08