SCOPe 2.07: Domain d6f5ha1: 6f5h A:207-560

Lineage for d6f5ha1 (6f5h A:207-560)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (6 proteins)
   Pfam PF00443

6. Protein Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) [82569] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82570] (25 PDB entries)

8. Domain d6f5ha1: 6f5h A:207-560 [350895]
   Other proteins in same PDB: d6f5ha2
   automated match to d1nb8b_
   complexed with cq5, gol, so4

Details for d6f5ha1

PDB Entry: 6f5h, 2.16 Å

PDB Description: crystal structure of usp7 in complex with a 4-hydroxypiperidine based inhibitor

PDB Compounds: (A:) Ubiquitin carboxyl-terminal hydrolase 7

SCOPe Domain Sequences for d6f5ha1:

Sequence, based on SEQRES records:

>d6f5ha1 d.3.1.9 (A:207-560) Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) {Human (Homo sapiens) [TaxId: 9606]}
skkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfye
lqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfrg
kmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehgl
qeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdpa
nyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnygghdddls
vrhctnaymlvyiresklsevlqavtdhdipqqlverlqeekrieaqkrkerqe

Sequence, based on observed residues (ATOM records):

>d6f5ha1 d.3.1.9 (A:207-560) Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) {Human (Homo sapiens) [TaxId: 9606]}
skkhtgyvglknqgatcymnsllqtlfftnqlrkavymmptegddssksvplalqrvfye
lqhsdkpvgtkkltksfgwetldsfmqhdvqelcrvlldnvenkmkgtcvegtipklfrg
kmvsyiqckevdyrsdrredyydiqlsikgkknifesfvdyvaveqldgdnkydagehgl
qeaekgvkfltlppvlhlqlmrfmydpqtdqnikindrfefpeqlpldeflqktdpkdpa
nyilhavlvhsgdnhgghyvvylnpkgdgkwckfdddvvsrctkeeaiehnyggrhctna
ymlvyiresklsevlqavtdhdipqqlverlqeekrieaqkrkerqe

Timeline for d6f5ha1:

• d6f5ha1 is new in SCOPe 2.07-stable
  
• d6f5ha1 appears in the current release, SCOPe 2.08