SCOPe 2.05: Domain d9icda_: 9icd A:

Lineage for d9icda_ (9icd A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein Isocitrate dehydrogenase, ICDH [53668] (2 species)

7. Species Escherichia coli [TaxId:562] [53669] (27 PDB entries)

8. Domain d9icda_: 9icd A: [35075]
   complexed with nap

Details for d9icda_

PDB Entry: 9icd, 2.5 Å

PDB Description: catalytic mechanism of nadp+-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and nadp+ complexes

PDB Compounds: (A:) isocitrate dehydrogenase

SCOPe Domain Sequences for d9icda_:

Sequence; same for both SEQRES and ATOM records:

>d9icda_ c.77.1.1 (A:) Isocitrate dehydrogenase, ICDH {Escherichia coli [TaxId: 562]}
skvvvpaqgkkitlqngklnvpenpiipyiegdgigvdvtpamlkvvdaavekaykgerk
iswmeiytgekstqvygqdvwlpaetldlireyrvaikgplttpvgggirslnvalrqel
dlyiclrpvryyqgtpspvkhpeltdmvifrensediyagiewkadsadaekvikflree
mgvkkirfpehcgigikpcseegtkrlvraaieyaiandrdsvtlvhkgnimkftegafk
dwgyqlareefggelidggpwlkvknpntgkeivikdviadaflqqillrpaeydviacm
nlngdyisdalaaqvggigiapganigdecalfeathgtapkyagqdkvnpgsiilsaem
mlrhmgwteaadlivkgmegainaktvtydferlmdgakllkcsefgdaiienm

Timeline for d9icda_:

• d9icda_ first appeared (with stable ids) in SCOP 1.55, called d9icd__
  
• d9icda_ appears in SCOPe 2.04
  
• d9icda_ appears in SCOPe 2.06
  
• d9icda_ appears in the current release, SCOPe 2.08