SCOP 1.63: Domain d9icd__: 9icd -

Lineage for d9icd__ (9icd -)

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenases [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudodyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenases [53659] (2 families)

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
   the active site is between the two identical subunits

6. Protein Isocitrate dehydrogenase, ICDH [53668] (2 species)

7. Species Escherichia coli [TaxId:562] [53669] (23 PDB entries)

8. Domain d9icd__: 9icd - [35075]
   complexed with nap

Details for d9icd__

PDB Entry: 9icd, 2.5 Å

PDB Description: catalytic mechanism of nadp+-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and nadp+ complexes

SCOP Domain Sequences for d9icd__:

Sequence; same for both SEQRES and ATOM records:

>d9icd__ c.77.1.1 (-) Isocitrate dehydrogenase, ICDH {Escherichia coli}
skvvvpaqgkkitlqngklnvpenpiipyiegdgigvdvtpamlkvvdaavekaykgerk
iswmeiytgekstqvygqdvwlpaetldlireyrvaikgplttpvgggirslnvalrqel
dlyiclrpvryyqgtpspvkhpeltdmvifrensediyagiewkadsadaekvikflree
mgvkkirfpehcgigikpcseegtkrlvraaieyaiandrdsvtlvhkgnimkftegafk
dwgyqlareefggelidggpwlkvknpntgkeivikdviadaflqqillrpaeydviacm
nlngdyisdalaaqvggigiapganigdecalfeathgtapkyagqdkvnpgsiilsaem
mlrhmgwteaadlivkgmegainaktvtydferlmdgakllkcsefgdaiienm

Timeline for d9icd__:

• d9icd__ first appeared (with stable ids) in SCOP 1.55
  
• d9icd__ appears in SCOP 1.61
  
• d9icd__ appears in SCOP 1.65
  
• d9icd__ appears in the current release, SCOPe 2.08, called d9icda_