SCOPe 2.08: Domain d6bmwa3: 6bmw A:219-525

Lineage for d6bmwa3 (6bmw A:219-525)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein automated matches [190252] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187034] (47 PDB entries)

8. Domain d6bmwa3: 6bmw A:219-525 [349756]
   Other proteins in same PDB: d6bmwa1, d6bmwa2, d6bmwb1, d6bmwb2
   automated match to d2shpa1
   complexed with 5od, dzs, gol, po4

Details for d6bmwa3

PDB Entry: 6bmw, 2.1 Å

PDB Description: non-receptor protein tyrosine phosphatase shp2 in complex with allosteric inhibitors shp099 and shp504

PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d6bmwa3:

Sequence, based on SEQRES records:

>d6bmwa3 c.45.1.2 (A:219-525) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietl

Sequence, based on observed residues (ATOM records):

>d6bmwa3 c.45.1.2 (A:219-525) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklqgfweefetlqqqeckllysrkegqrqenknknryknilpfd
htrvvlhpvsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivmttkevergk
skcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwp
dhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgv
dcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

Timeline for d6bmwa3:

• d6bmwa3 first appeared in SCOPe 2.07