SCOPe 2.02: Domain d1cd2a_: 1cd2 A:

Lineage for d1cd2a_ (1cd2 A:)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (6 species)

7. Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (23 PDB entries)

8. Domain d1cd2a_: 1cd2 A: [34919]
   complexed with fol, nap

Details for d1cd2a_

PDB Entry: 1cd2, 2.2 Å

PDB Description: ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and nadp+

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1cd2a_:

Sequence; same for both SEQRES and ATOM records:

>d1cd2a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Fungus (Pneumocystis carinii) [TaxId: 4754]}
mnqqksltlivalttsygigrsnslpwklkkeisyfkrvtsfvptfdsfesmnvvlmgrk
twesiplqfrplkgrinvvitrnesldlgngihsaksldhalellyrtygsessvqinri
fviggaqlykaamdhpkldrimatiiykdihcdvffplkfrdkewssvwkkekhsdlesw
vgtkvphgkinedgfdyefemwtrdl

Timeline for d1cd2a_:

• d1cd2a_ first appeared (with stable ids) in SCOP 1.55
  
• d1cd2a_ appears in SCOPe 2.01
  
• d1cd2a_ appears in SCOPe 2.03
  
• d1cd2a_ appears in the current release, SCOPe 2.08