Lineage for d2dhfa_ (2dhf A:)

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1871769Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 1871770Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 1871771Family c.71.1.1: Dihydrofolate reductases [53598] (4 protein domains)
  6. 1871959Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 1872006Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)
  8. 1872074Domain d2dhfa_: 2dhf A: [34912]
    complexed with dzf

Details for d2dhfa_

PDB Entry: 2dhf (more details), 2.3 Å

PDB Description: crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazofolate
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d2dhfa_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2dhfa_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2dhfa_:

Click to download the PDB-style file with coordinates for d2dhfa_.
(The format of our PDB-style files is described here.)

Timeline for d2dhfa_: