SCOP 1.75: Domain d1dhfb_: 1dhf B:

Lineage for d1dhfb_ (1dhf B:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (25 PDB entries)

8. Domain d1dhfb_: 1dhf B: [34911]
   complexed with fol

Details for d1dhfb_

PDB Entry: 1dhf, 2.3 Å

PDB Description: crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazofolate

PDB Compounds: (B:) dihydrofolate reductase

SCOP Domain Sequences for d1dhfb_:

Sequence; same for both SEQRES and ATOM records:

>d1dhfb_ c.71.1.1 (B:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
lncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsipek
nrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssvyke
amnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfevye
kn

Timeline for d1dhfb_:

• d1dhfb_ first appeared (with stable ids) in SCOP 1.55
  
• d1dhfb_ appears in SCOP 1.73
  
• d1dhfb_ appears in SCOPe 2.01
  
• d1dhfb_ appears in the current release, SCOPe 2.08