SCOPe 2.07: Domain d1dhfa_: 1dhf A:

Lineage for d1dhfa_ (1dhf A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (79 PDB entries)

8. Domain d1dhfa_: 1dhf A: [34910]
   complexed with fol

Details for d1dhfa_

PDB Entry: 1dhf, 2.3 Å

PDB Description: crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazofolate

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1dhfa_:

Sequence; same for both SEQRES and ATOM records:

>d1dhfa_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
lncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsipek
nrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssvyke
amnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfevye
kn

Timeline for d1dhfa_:

• d1dhfa_ first appeared (with stable ids) in SCOP 1.55
  
• d1dhfa_ appears in SCOPe 2.06
  
• d1dhfa_ appears in the current release, SCOPe 2.08