SCOPe 2.05: Domain d1dlsa_: 1dls A:

Lineage for d1dlsa_ (1dls A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (63 PDB entries)

8. Domain d1dlsa_: 1dls A: [34906]
   complexed with mtx, ndp

Details for d1dlsa_

PDB Entry: 1dls, 2.3 Å

PDB Description: methotrexate-resistant variants of human dihydrofolate reductase with substitution of leucine 22: kinetics, crystallography and potential as selectable markers

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1dlsa_:

Sequence; same for both SEQRES and ATOM records:

>d1dlsa_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdypwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d1dlsa_:

• d1dlsa_ first appeared (with stable ids) in SCOP 1.55, called d1dls__
  
• d1dlsa_ appears in SCOPe 2.04
  
• d1dlsa_ appears in SCOPe 2.06
  
• d1dlsa_ appears in the current release, SCOPe 2.08